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Herbs & Supplements

Apricot Vine
Scientific Name: Passion Flower
Other Names: Corona de Cristo, Granadilla, Maypop, Passiflora incarnata, Passion Vine, Water Lemon

References

Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawl [sic]: a double-blind randomized controlled trial. Journal of Clinical Pharmacy and Therapeutics. 2001;25(5):369-373.

Akhondzadeh S, Naghavi HR, Shayeganpour A, Rashidi A, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of Clinical Pharmacy and Therapeutics. 2001;26(5):363-367.

Anon: Passion flower. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. March 1999.

Argento A, Tiraferri E, Marzaloni M. Oral anticoagulants and medicinal plants. An emerging interaction. [Article in Italian] Annals of Italian Medicine International. 2000;15(2):139-143.

Birner J, Nicolls JM. Passicol, an antibacterial and antifungal agent produced by Passiflora plant species: preparation and physicochemical characteristics. Antimicrobial Agents in Chemotherapy. 1973;3(1):105-109.

Block KI, Gyllenhaal C, Mead MN. Safety and efficacy of herbal sedatives in cancer care. Integrated Cancer Therapy. 2004;3(2):128-148.

Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study vs placebo. Fundamental Clinical Pharmacology. 1997;11(2):127-132.

California Rare Fruit Growers. Passion Flower. 1996. Available at: http://www.crfg.org/pubs/ff/passionfruit.html Accessed October 15, 2003.

Cauffield JS, Forbes HJ. Dietary supplements used in the treatment of depression, anxiety, and sleep disorders. Lippincott's Primary Care Practice. 1999;3(3):290-304.

Cuzzolin L, Zaffani S, Benoni G. Safety implications regarding use of phytomedicines. European Journal of Clinical Pharmacology. 2006;62(1):37-42.

Della Loggia R, Tubaro A, Redaelli C. Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them. [Article in Italian] Riv Neurol. 1981;51(5):297-310.

Dhawan K, Dhawan S, Chhabra S. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. Journal of Pharmacy and Pharmaceutical Science. 2003;6(2):215-222.

Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Journal of Ethnopharmacology. 2001;78:165-170.

Dhawan K, Kumar S, Sharma A. Anxiolytic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia. 2001;72(8):922-926.

Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. Journal of Toxicology and Clinical Toxicology. 2000;38(1):63-66.

Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metabolism and Disposition. 2006;34(4):577-582.

Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana. Annals of Allergy, Asthma and Immunology. 1997;79(5):449-454.

Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Medicine Review. 2000;4(3):229-251.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. American Journal of Health System Pharmacy. 2000;57(13):1221-1230.

Hoffmann DL. Passion flower. Herbal Materia Medica. No date given. Available at: http://www.healthy.net/asp/templates/article.asp?PageType=article&ID=1438. Accessed October15, 2003.

Ichimura T, Yamanaka A, Ichiba T, et al. Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats. Bioscience, Biotechnology, and Biochemistry. 2006;70(3):718-721.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Krenn L. Passion Flower (Passiflora incarnata L.)--a reliable herbal sedative. [Article in German] Wiener Medizinische Wochenschrift. 2002;152(15-16):404-406.

Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Systematic Review. 2007 Jan 24;(1):CD004518.

Morton J. Passionfruit. In: Morton J. Fruits of Warm Climates. Miami, Florida. J Morton Press; 1987:320-328.

Mourvaki E, Gizzi S, Rossi R, Rufini S. Passionflower fruit-a "new" source of lycopene? Journal of Medicinal Food. 2005;8(1):104-106.

Natural Medicines Comprehensive Database, Online Edition. Pharmacist's Letter/Prescriber's Letter. Stockton CA: Therapeutic Research Facility, 2006. Available at: http://www.pharmacistsletter.com/(S(ulqz3s45omt3ag55um4kj345))/home.aspx?li=1&st=1&cs=&s=ND.

Nicolls JM, Birner J, Forsell P Passicol, an antibacterial and antifungal agent produced by Passiflora plant species: qualitative and quantitative range of activity. Antimicrobial Agents in Chemotherapy. 1973;3(1):110-117.

Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: Stonesong Press; 1999.

Pelegrini PB, Noronha EF, Muniz MA, et al. An antifungal peptide from passion fruit (Passiflora edulis) seeds with similarities to 2S albumin proteins. Biochim Biophys Acta. 2006;1764(6):1141-1146.

Reginatto FH, De-Paris F, Petry RD, et al. Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species. Phytotherapy Research. 2006;20(5):348-351.

Salgueiro JB, Ardenghi P, Dias M, Ferreira MB, Izquierdo I, Medina JH. Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacology, Biochemistry, and Behavior.1997;58(4):887-891.

Shinomiya K, Inoue T, Utsu Y, et al. Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biological and Pharmaceutical Bulletin. 2005;28(5):808-810.

Spencer KC, Seigler DS. Cyanogenesis of Passiflora edulis. Agricultural and Food Chemistry. 1983;31(4):794-796.

Speroni E, Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Medica. 1988;54(6):488-491.

Spinella M. Herbal Medicines and Epilepsy: The Potential for Benefit and Adverse Effects. Epilepsy and Behavior. 2001;2(6):524-532.

Werneke U, Turner T, Priebe S. Complementary medicines in psychiatry: review of effectiveness and safety. British Journal of Psychiatry. 2006;188:109-121.

Wolfman C, Viola H, Paladini A, Dajas F, Medina JH. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacology, Biochemistry, and Behavior. 1994;47(1):1-4.

Last Revised May 18, 2007

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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